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Glossary

MoCRA

Full name: Modernization of Cosmetics Regulation Act
MoCRA, the Modernization of Cosmetics Regulation Act, is U.S. legislation signed into law in December 2022 that significantly expands FDA's regulatory authority over cosmetics and personal care products, representing the first major update to cosmetics regulation since the original Food, Drug and Cosmetic Act of 1938. MoCRA introduces mandatory facility registration, product listing, adverse event reporting, safety substantiation requirements and, for the first time, mandatory Good Manufacturing Practice compliance for cosmetics manufacturers. 

Quick facts

Category U.S. cosmetics and personal care regulatory framework
Used by Cosmetics and personal care product manufacturing
Also called MoCRA
Related standards GMP
Related processes Document control, customer feedback management, supplier management, risk assessment
Semantic match MoCRA, Modernization of Cosmetics Regulation Act, cosmetics FDA regulation, cosmetics GMP requirements

What is MoCRA?

MoCRA represents a substantial expansion of FDA's authority over cosmetics, an area that had previously operated under far lighter regulatory oversight than other FDA-regulated product categories such as drugs, medical devices and food.

Under MoCRA, manufacturers and processors must register their facilities with the FDA and renew that registration periodically, and companies must list each cosmetic product they distribute in the United States with the agency. Previously voluntary practices, such as reporting adverse events and serious adverse events, are now mandatory.

MoCRA also requires cosmetic companies to maintain safety substantiation records, evaluated by qualified experts, and for the first time makes GMP compliance mandatory for cosmetics manufacturers rather than a voluntary best practice. The law additionally establishes FDA authority to order a mandatory recall if a product is deemed harmful to consumers.

Why is MoCRA important?

MoCRA fundamentally changes the compliance landscape for cosmetics companies, many of which previously operated with minimal formal regulatory obligations compared to other FDA-regulated industries.

Mandatory GMP compliance means cosmetics manufacturers must now build the kind of documented, controlled quality systems that pharmaceutical and medical device companies have long been required to maintain, representing a significant operational shift for many smaller cosmetics companies.

The law's mandatory recall authority and adverse event reporting requirements increase the stakes of safety failures, making proactive safety substantiation and quality documentation more important than ever for companies in this space.

How does MoCRA work?

MoCRA's key requirements include:

  1. Facility registration. Register manufacturing and processing facilities with the FDA, renewing every two years.
  2. Product listing. List each cosmetic product distributed in the United States with the FDA.
  3. Adverse event reporting. Report adverse events and serious adverse events to the FDA.
  4. Safety substantiation. Maintain records substantiating product safety, evaluated by qualified experts.
  5. GMP compliance. Implement mandatory Good Manufacturing Practice controls.
  6. Recall response. Comply with FDA's authority to order a mandatory recall when warranted.

MoCRA vs. Prior Cosmetics Regulation

Comparison Before MoCRA Under MoCRA
GMP compliance Voluntary Mandatory
Adverse event reporting Voluntary Mandatory
Facility registration Not required Required, renewed every two years

Real-world examples of MoCRA

A cosmetics manufacturer registers its production facility with the FDA for the first time under MoCRA, establishing a renewal process to keep the registration current every two years.

A personal care product company builds a formal safety substantiation file for a new product line, engaging a qualified expert to evaluate and document the product's safety before market launch.

A cosmetics brand implements GMP-based quality controls for the first time, documenting procedures and training personnel to meet MoCRA's new mandatory manufacturing requirements.

Regulations and standards related to MoCRA

MoCRA was signed into law as part of the Consolidated Appropriations Act 2023, amending the Federal Food, Drug and Cosmetic Act to expand FDA's cosmetics oversight authority, with implementing regulations continuing to develop as FDA issues further guidance.

Because MoCRA introduced mandatory GMP requirements where none previously existed for cosmetics, companies should confirm current FDA guidance on specific GMP expectations as this area of regulation continues to mature.

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How QT9 helps with MoCRA

QT9 QMS MoCRA capabilities

  • Manage MoCRA compliance and synchronize documentation with anyone, anywhere.
  • Get comprehensive tools to document, monitor and manage GMP processes.
  • Automate the collection, analysis and reporting of adverse events to the FDA.
  • Simplify facility and product registrations with centralized data and automated reminders.
  • Facilitate gathering, evaluation and storage of product safety substantiation data.
  • Enable built-in traceability for faster response to potential recalls.

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Common mistakes with MoCRA

Common mistakes include underestimating the operational shift required to implement mandatory GMP controls for the first time, particularly for smaller cosmetics companies without prior quality system infrastructure.

Other problems include treating facility registration and product listing as one-time tasks rather than ongoing obligations requiring renewal and updates as products and facilities change.

Frequently asked questions

MoCRA was signed into law on December 29, 2022, as part of the Consolidated Appropriations Act 2023, representing the first major update to FDA's cosmetics regulatory authority since 1938.
No. GMP compliance for cosmetics manufacturers was voluntary before MoCRA, which made it a mandatory requirement for the first time, aligning cosmetics regulation more closely with other FDA-regulated industries.
Yes. MoCRA requires cosmetics manufacturers and processors to register their facilities with the FDA and renew that registration every two years.
Safety substantiation refers to the records cosmetics companies must maintain demonstrating a product's safety, based on evaluation by qualified experts, a requirement introduced by MoCRA.
Yes. MoCRA established FDA authority to order a mandatory recall if the agency determines a cosmetics product is harmful to consumers, a new enforcement power not previously available for this product category.
Yes. MoCRA requires cosmetics companies to report adverse events and serious adverse events to the FDA, a shift from the previously voluntary reporting practice.

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Last reviewed: July 21, 2026